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3.2 Histological assessment In the second-week sections of the S group, numerous oval-nucleated cells, widespread pathological adipogenesis, fibril disorganization, edema, and inflammatory cell infiltrations were observed (Figure 6A)

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A rapid anti-AMG 966 antibody response was observed, with 5 of 6 dosed subjects in cohort 1 testing positive for ADA at day 15, the first post-dose time point ( Figure 2A )