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When activated, Egr-1 induces the expression of numerous genes that play critical roles in cell growth, survival, and blood vessel formation

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This process requires specific nutrients, including: Vitamin C : Works synergistically with glutathione and helps to regenerate it

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Indeed, for several xenobiotics, a major site for cysteine S -conjugate formation appears to be the kidney (Hassal et al., 1984, Kanhai et al., 1989, Koob and Dekant, 1990)