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Along these same lines, the BosR-dependent toxicity associated with overexpression of RpoS in vitro likely reflects overexpression of RpoS-upregulated genes and/or reduced expression of one or more essential gene products due to competition with RNAP-RpoD (84)

Additionally, both metabolites also deactivated autophagy and induced apoptosis in LPS challenged macrophages

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Based on your detailed feedback, we may suggest: Splitting the full dose into two smaller injections spaced apart