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Malfunctions of the pituitary, adrenal cortex, and gonads markedly impair hepatic drug metabolism in rats

Improvements in all skin issues should be visible after a month of usage, which is rather fast

Fauconnier 2000

The rats were given daily injections of tesofensine plus a fixed dose of 5-HTP (31 mg/kg, i.p.) and CB (75 mg/kg, i.p.) for 15 days, following one of six protocols: vehicle (control, n = 6 for each group), 5-HTP/CB (31 and 75 mg/kg), tesofensine1 (1 mg/kg, s.c.), tesofensine2 (2 mg/kg, s.c.), tesofensine1 + 5-HTP/CB, and tesofensine2 + 5-HTP/CB

doi: 10.1002/eji.201444856 71 TakedaAHollmnMDermadiDPanJBruloisKFKaukonenRet al