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Abnormal tau phosphorylation reduces its microtubule affinity, promoting aggregation into NFTs and paired helical filaments

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Decoding Alzheimers disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies

Furthermore glycemic control deteriorates following exposure to a single supraphysiological dose of human GH in hypophysectomized adults with type 1 diabetes mellitus (84)
Cases of hyperuricemia have also increased dramatically over the last 50 years, with an estimated 43.3 million Americans now affected 2

2017;26:509e5226
