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Since hsp-90 is a well-known target of HSF-1, it is conceivable that depleting HSF-1 may impair the proper induction of the UPR ER upon heat- or tunicamycin-induced stress due to insufficient HSP-90 levels

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Aromatic amino acids, such as tryptophan (Trp) and tyrosine (Tyr), are easily oxidized (52)

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J Biol Chem 226:497509 Frster J, Famili I, Fu P, Palsson B, Nielsen J (2003) Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network