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NK cells and CD3 + , CD4 + , and CD8 + T lymphocytes are currently thought to be the primary immune cells in the TME, with CD8 + T lymphocytes playing a significant role in tumor killing (83, 84)

In summary, microbial metabolites exerted diverse immunoregulatory effects in asthma, ranging from protective activities such as maintaining epithelial integrity and promoting Treg differentiation, to pathogenic actions including mucus hypersecretion, eosinophilic infiltration, and Th17-driven inflammation

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ALT2 inhibition and deletion have no effect on APAP hepatotoxicity To test the hypothesis that ALT2 has a role in APAP-induced liver injury, we first used a pharmacological approach

J Inorg Biochem 100:16791684 Tang D, Chen X, Kang R, Kroemer G (2021) Ferroptosis: molecular mechanisms and health implications