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3A) 44,45,46

Geldanamycin and its 17-allyl-amino-a7-demethoxy analogue overcome Ad-mda7 resistance in lung cancer

Do not exceed stated dose unless directed by a healthcare practitioner.

Drugs with narrow therapeutic range and strong toxic side effects

The results showed that higher doses raised antioxidant activity, and lessened oxidative stress and inflammatory biomarkers

Since the synthesis and expression of GPx4 are regulated by various cellular processes, targeting GPx4 may constitute a promising strategy for the induction of ferroptosis and the promotion of cancer cell death in treatment-resistant cancers (Lee and Roh 2023)