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Upregulation of ERK, P38 MAP kinase, and JNK pathways was found to be responsible for the effects, which potentially show the involvement of Nrf2 phosphorylation [228]

Figure 7 BMSCs play a key role in remodeling the leukemia niche

139,140 In addition, recently, IDH1 and IDH2 gene mutations have been prevalent in several diverse malignancies, including glioma, AML, angioimmunoblastic lymphomas, chondrosarcoma, and melanomas

These cells remain sequestered in the dermis for months to years, where the Tyndall effect translates deep-seated pigment into a clinically characteristic gray-blue hue [156]

PTER has great biological potential due to its ability to activate metabolic pathways related to protection against OS, mitochondrial dysfunction, inflammation, intracellular calcium restoration and cognitive function, thus resulting in a neuroprotective function against the pathogenic mechanisms of ALS

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