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In studies using obese murine models, AOD9604 administration was associated with increased lipolysis that coincided with elevated 3-AR mRNA expression, supporting the hypothesis that the peptide sensitizes fat cells to lipolytic signaling rather than simply forcing fat breakdown through a separate pathway

studies exploring insulin sensitivity

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In addition to impairing insulin signaling, adipocyte derived FAs can also impact gluconeogenesis in the liver, where a hallmark of T2D is the loss of the inverse relationship between gluconeogenesis and lipogenesis