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Free Radic Biol Med 33:12901300 Kannan R, Mittur A, Bao Y, Tsuruo T, Kaplowitz N (1999) GSH transport in immortalized mouse brain endothelial cells: evidence for apical localization of a sodium-dependent GSH transporter
Once NAC is inside the cells it is rapidly hydrolyzed, then cytosolic acylase I deacetylates NAC ( Figure 2Antioxidant activity of NAC.Increasing reactive oxygen species (ROS) depletes the antioxidant enzymes in the cells

[DOI] [PMC free article] [PubMed] [Google Scholar] Arnold SE, Arvanitakis Z, Macauley-Rambach SL, Koenig AM, Wang HY, Ahima RS, Craft S, Gandy S, Buettner C, Stoeckel LE, Holtzman DM, Nathan DM

[PubMed: 3443807] 82

Increase Vitamin C Intake Vitamin C is another powerful antioxidant that plays a supportive role in maintaining glutathione levels

Protects Against Environmental Damage:Shields skin from free radicals, sun exposure, and environmental aggressors
