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Similarly, in 2005 and 2006, three clinical trials of LC supplementation in patients with HE were conducted, with levels of evidence of 1b, 2b, and 2b, respectively, showing that LC significantly improved the patients condition [50,51,52]
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BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells

These enzymes control key steps in melanin synthesis