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Key Summary Melasma is one of the most common and stubborn skin pigmentation concerns

KPV downregulates inflammatory signaling including NF-kB in preclinical models, which is the basis for interest in inflammatory skin conditions

Patients with uncontrolled AH also exhibit elevated intracellular Ca 2+ levels [304], although these authors did not investigate the potential role of oxidative damage or eryptosis in this context

Pectin structure and biosynthesis

Concise review: Emerging role of CD44 in cancer stem cells: A promising biomarker and therapeutic target

It is important to highlight that flavonoid compounds are poorly absorbed in the gut and their concentrations in target tissues are often too low to perform an effective antioxidant defense as reviewed by Surai [105]