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In innate cells, particularly myeloid cells, granulocytes, NK cells, and DCs, these responses are generally initiated by the exposure of extracellular and intracellular pattern recognition receptors (PRRs) to various stimuli associated with pathogens or other insults

This snowball effect overwhelms the detoxification pathways, causing more oxidative stress, which leads to immune system activation and sometimes allergies

Iwata Y, Nishino T, Takayama S, Koizumi N

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For prohibition, a substance or method must meet at least two of the following criteria based on a decision made by the WADA List Committee: This framework enables WADA to address both established performance-enhancing agents and new substances that present health or integrity risks to sport