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Sensory information from the abdominal organs traverses the vagus nerve to the nucleus of the solitary tract in the brainstem, with projections to several other areas of the CNS, including the cerebral cortex and medulla oblongata (Liu and Forsythe, 2021)

[DOI] [PubMed] [Google Scholar] 92.McGinley M.P., Goldschmidt C.H., Rae-Grant A.D

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The mutations in the trimethyl lysine hydroxylase epsilon (TMLHE) gene, the products of this gene being the first enzyme in carnitine biosynthesis, have been linked to ASD [21, 88-91]

Thus, the enhanced invasion and migration activities observed upon AngII stimulation in our in vitro experiments are likely mediated primarily through ERK/NFB/EMT signaling rather than through metabolism upregulation, consistent with the modest magnitude of OCR/ECAR changes

Importantly, pro-oxidant NAC effects were not observed at concentrations of 50 or 500 mg/kg making pro-oxidative actions of NAC in present study highly unlikely