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10.1152/ajplung.00149.2010 [DOI] [PMC free article] [PubMed] [Google Scholar] Hinz B

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For the uterine environment to be receptive to pregnancy, there must be activation, differentiation, and expansion of toleragenic dendritic cells (tDCs) and CD4 + CD25 + Treg cells (90, 91) Evidence from a CBAxDBA/2 mouse model of pregnancy failure suggests that components of seminal fluid prime the immunological landscape of the uterine environment for implantation (92)

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These injections are typically administered intramuscularly , although some protocols allow for MIC B12 injections to be administered subcutaneously or intramuscularly , depending on clinical preference