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Most of these are in southeast Africa or Central America

[DOI] [PubMed] [Google Scholar] 169.Kim JY, van de Wall E, Laplante M, Azzara A, Trujillo ME, Hofmann SM, et al

As we age, NAD levels naturally decline, which has been associated with various age-related health issues, including metabolic disorders, neurodegenerative disease, and reduced cellular repair mechanisms

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Disorders of the small or large intestine, including inflammatory bowel disease (IBD), can interfere with your dogs ability to absorb many nutrients, including B12

NAD + and precursors supplementation NAD + can be directly supplemented intravenously to increase cellular NAD + levels, which has been observed in healthy and elderly cohorts, suggesting improvements in cognitive function and increased expression of antioxidant genes, although these trials were conducted in small cohorts 66,116,117