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Altunay,

Long-Term Safety Concerns The biggest gap in our understanding of BPC-157 isnt its short-term useits what happens with chronic or long-term exposure in humans

MDPI Jozwiak M et al

4.2 Prebiotics as critical modulators of gut-thyroid homeostasis Prebiotics, indigestible dietary fibers that selectively stimulate the growth and activity of beneficial gut bacteria, serve as essential adjuncts to probiotic therapy and independently contribute to hypothyroidism management (Ouyang et al., 2024)

Briefly, animals were assigned to two groups ( n = 5 male mice per group), vehicle (5% DMSO and 0.5% Kollidon-30 in 100 mM sodium phosphate buffer) or TLC-2716 (1 mg per kg (body weight) daily by oral gavage) for 8 days, after which animals were humanely killed by cardiac puncture, and plasma and tissues were collected for lipid and gene expression endpoints as described below

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