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Steady-state kinetics were measured using a pyrophosphate assay for the apo and AdoCbl-bound dark/light states of the Ab DPcob protein, as well as the truncated DGC domain only (Fig

However, a recent large global, multicenter phase II study of HCC showed that ADI-PRG-20 combined with 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) was associated with an ORR of 9.3% versus 8.15% with FOLFOX4

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