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Ethical approval for the use of samples obtained from PLWH treated with IMC-M113V was obtained through the IMC-M113V-103 study (EudraCT 2021-002008-11, 29 Oct 2021), which was approved by the relevant ethics bodies at each participating site as indicated in the Study design and participants section

It is usually caused by infections such as Streptococcus pneumoniae, Haemophilus influenzae, and respiratory viruses [6]

(c) tolerance to short peptides that may bind directly to MHC in nonprofessional antigen-presenting cells (APCs)

The late-phase response involves neutrophils and eosinophils, followed by macrophages and lymphocytes

Originally discovered in human gastric juice, this peptide acts as a foundational signaling molecule for mucosal protection and internal balance (homeostasis)
