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The pKa of a drug influences solubility, lipophilicity, protein binding and permeability and is of paramount importance to the overall characteristics of a drug [56]

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4.3 Current research gaps and future directions Current pharmacogenomic studies in SLE predominantly focus on single-drug and single-gene associations, with limited exploration into polygenic interactions or the effects of genedrug combination therapies on toxicity profiles

57,350 Many lines of evidence have found that tumor resistance is caused by cells and the external environment in which the cells are located

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