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These data illustrate that zonulin overexpression may be implicated in the pathogenesis of chronic inflammatory diseases, including inflammatory bowel disease, and autoimmune diseases (56)

Recently, Wald et al (1998) estimated the risk of ischemic heart disease (angina pectoris or myocardial infarction) from eight retrospective studies and from their own positive prospective study, the British United Provident Association study, as a function of homocysteine level

In order to control the activity of antioxidant enzymes, they also function as cofactors [210]

As known, uncontrolled DM may be the main cause of mortality among people[4]

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Recently, we have shown that oral administration of combined micronutrients such as vitamin A (10 5 IU), vitamin E (2500 IU) and zinc sulphate (60 ppm) from one month before the expected calving date until calving lowers stress levels and improves the immune response of dairy cows and subsequently the well-being of their calves (12)