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Acknowledgments We acknowledge the Core Facility of Basic Medical Sciences, Changzhi Medical College, for their technical support

Understanding why this variability exists requires examining the mechanisms more closely

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Entacapone is a specific peripheral catechol- O -methyltransferase inhibitor approved by the US FDA in 1999 to treat patients with advanced Parkinsons disease as an adjuvant drug

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Biochemistry 23, 18881894
