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Research indicates that combined supplementation with selenium and vitamin E synergistically enhances the antioxidant defense capacity of colonic epithelium, reducing ferroptosis levels induced by dysbiosis and thereby significantly alleviating the pathological progression of experimental colitis (169)

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observed that cyclooxygenase-2 and ACSL4 expression were elevated in the S100-mediated autoimmune hepatitis models, accompanied by the downregulated expression of FTH1 and GPX4