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Investigations into the effects of microplastics on the neuroendocrine system via the gut-brain axis revealed that exposure to 50 m MPs significantly reduced colonic mucin production and induced substantial alterations in the gut microbiota, in the 50 m - 100 g/L exposure group, a marked decrease in oxytocin (OT) content in the medial prefrontal cortex was observed, along with damage to the bloodbrain barrier, these findings highlight the potential adverse effects of environmental microplastic exposure on the neuroendocrine framework in social mammals, including humans (27)

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doi: 10.3168/jds.2020-19116 123 KhaniNShakeriAHMoosavyMHSoleymani FardMAbedi SoleimaniRKhorramiRet al

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Pancreatic islet tissue disorder induced by fibrosis is another important mechanism of -cell failure [7, 31]

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