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[73] [74] [75] It is synthesized by some bacteria in the gut microbiota in humans and other animals, but it has long been thought that humans cannot absorb this as it is made in the colon, downstream from the small intestine, where the absorption of most nutrients occurs

You can find more scientific research on B12's role from sources like the National Institutes of Health

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For many people, especially those with certain health conditions, this process doesn't work well