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Of note, these factors that dictate the plasticity and differentiation state of melanoma cells are also decisive for the efficacy of targeted therapy

Simultaneously, higher S-adenosylmethionine (SAM) availability supports key methylation-dependent pathways, which are crucial for epigenetic regulation and gene expression related to energy metabolism

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John Lieurance of MitoZen Scientific
Redox Signal 19 , 708722 (2013)