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This lack of bioavailabilitythe degree to which a substance becomes available to the target tissueis why many people fail to see results from traditional pills or powders

- An elevated homocysteine with an elevated MMA indicates a B12 deficiency but does not eliminate the possibility of a folate deficiency

Plant and Cell Physiology 51, 2010
Importantly, folic acid should not be given alone before B12 deficiency is excluded or treated, as this can mask anaemia while allowing neurological damage to progress

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