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Common gastrointestinal side effects include nausea, diarrhoea, constipation, and abdominal pain, typically emerging during treatment initiation or dose escalation

Accelerating titration increases side effect risk (nausea, vomiting, GI discomfort) and doesn't necessarily accelerate fat loss proportionally

Glucagon-Like Peptide-1 Receptor Agonists and Cardiovascular Risk Reduction in Type 2 Diabetes Mellitus: Is It a Class Effect

Common research dosing for MOTS-c ranges from 5 mg to 10 mg, administered subcutaneously 35 times per week , or daily at lower doses (5 mg/day)

doi: 10.1007/s11239-021-02488-2

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