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Succinate and fumarate are intermediates in TCA cycle, while R-2-HG and S-2-HG as enantiomers are both byproducts with low concentration in normal cellular metabolism, while the accumulation of them greatly increased in abnormal circumstances [100]

In GBM, the metabolic profiling of GBM cell lines showed that the abundance of GTP nucleotides correlates with resistance to radiation therapy, while inhibition of GTP synthesis sensitized GBM cells to irradiation by impairing DNA repair [84]

Additionally, cocaine use in PLWH upregulates expression of activated leukocyte cell adhesion molecule in brain endothelium, promoting monocyte adhesion and transmigration across the BBB (131)

MN-CCPCA (M)

The dose-conversion to humans is not validated

TheSuper NAD+ IV Treatment contains: Saline 1000ml Normal saline solution is a sterile, isotonic mixture of water and sodium chloride, also known as 0.9% sodium chloride solution