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Another issue is pain

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In addition, examples from other biologic therapies, such as growth factors and gene therapy, that showed early promise but failed clinical translation underscore the importance of rigorous study design, safety monitoring, and realistic expectations in peptide research

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20 In the same year, Thakkar and Billa also compared the benefits of the different forms, and argued that methyl-B12 alone may not address the neurological complications in B12 deficiency that arise partly from the lack of adenosyl-B12