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Contrary to ALDH1F1 mutants no increased sensitivity is observed towards heat shock, DNA damage or oxidative stress in the ALDH1G1/ ALDH1G2 double knockouts, [6]

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Additionally, Zn supplementation has been found to aggravate body fat accumulation in both genetically obese mice and high-fat diet-induced obese mice, suggesting that Zn may interact with dietary fat consumption to exacerbate obesity ( Dyslipidemia and Zn overload Our study demonstrated that excessive Zn intake leads to significant dyslipidemia, with increased TG, total cholesterol, and very-low-density lipoprotein cholesterol (VLDL-C) levels, alongside decreased HDL-C levels (Shabana et al