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Immune Imbalance In response to exposure to various stimuli, naive CD4+ T cells differentiate into various subsets of T helper (Th) cells, including Th1, Th2, Th17, and T regulatory lymphocytes (Tregs)

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Oxidative damage to mtDNA leads to a positive feedback loop in ROS production as the ETC enzymes encoded by mtDNA are damaged, impairing the ETC and increasing electron leakage (Rice et al., 2011