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Indeed, mitophagy is activated in cold-exposed BAT, as shown by electron microscopy (EM) visualization of mitochondria inside autophagosomes and the upregulation of autophagy-related proteins [230, 234]

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Nat Rev Drug Discov 21 , 283305 (2022)

A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy