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Oxidative stress in OA pathophysiology It has long been suggested that OA arises from a cluster of multiple factors including genetic predisposition, obesity, trauma, aging and even the presence of other systemic diseases

DOI 10.1093/chemse/bjv061
doi: 10.1152/physrev.00041.2018 7
However, other groups have shown that efficient mTORC1 suppression is necessary to avoid MZB loss 39

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ALS: bulk of the iceberg Human neuroimaging and post-mortem studies show that impaired mitochondrial biology occurs early in the pathogenesis of ALS [54]