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KGFs have been investigated as a potential therapeutic approach for the prevention and treatment of oral mucositis following high dose chemotherapy and autologous hematopoietic stem cell transplant [136]

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255 Similarly, new advances in synthetic biology, such as the development of synthetic Notch receptors that allow localized and tightly regulated delivery of genetically encoded therapeutics at precise sites of tissue pathology, 256 open the possibility for locally presenting TGF- inhibitors at sites of non-malignant TGF--driven diseases such as tissue fibrosis

Lin and A.B

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