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This represents a significant advance over systemic or subcutaneous peptide delivery

This suggests that contacts outside of the ligand-binding site contribute to its improved affinity in the presence of ENL and, indeed, our model revealed an extensive interfacial interaction between CRBN and ENL YEATS, with a buried solvent-accessible surface area of ~2,258 2 and a high degree of shape complementarity (0.64 out of 1) 52

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doi: 10.1016/j.jmb.2018.12.015

doi: 10.1007/s10142-023-01273-z 66 LiuH.TangT

therefore, the rash is often well confined and has clear demarcations