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2011;7(3) doi: 10.1371/journal.pgen.1002013
These include immune-mediated cytokine release, hormonal modulation through the hypothalamicpituitaryadrenal (HPA) axis, and neural pathways involving both the enteric nervous system (ENS) and the vagus nerve (Guzzetta et al., 2022
using bioassays and in silico approaches
Although some progress has been made in research, the underlying mechanisms of depression remain poorly understood, highlighting the need for continued investigation to uncover its complex pathology and improve therapeutic outcomes
Kaback, & J
ER stress and oxidative stress are especially well-documented contributors to this effect (Yiqi et al., 2022)
