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Calcium-independent phospholipase A2 (iPLA2)-mediated lipid peroxidation detoxification is sufficient to inhibit p53-driven ferroptosis under ROS-induced stress and acts as a major ferroptosis suppressor independent of GPX4, suggesting that iPLA2 is a promising therapeutic tumor target (68)

Oxidative stress regulates the ubiquitin-proteasome system and immunoproteasome functioning in a mouse model of X-adrenoleukodystrophy

57,69,78,94,296 The ONATA study showed a negative correlation between serum uric acid levels and insulin sensitivity, suggesting a potential link between uric acid, insulin sensitivity, and the risk of developing hypertension

doi: 10.1016/j.cmet.2016.07.015 [DOI] [PMC free article] [PubMed] [Google Scholar] 95.Liang SX, Richardson DR

Most notably, researchers have reported an increase in DA neurons, levels of dopamine, improvements in motor function, and decreases in apoptosis following treatment