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Tabak et al., 2021)

Changing methyl group of N - methyl piperazine by p-methoxyphenyl, o-fluorophenyl, p-fluoropenyl, o-chlorophenyl, p- chlorophenyl, p-nitrophenyl or cyclohexyl groups resulted in PDE inhibitors with equal potency to sildenafil [37]

The parameters within the maxima detection remained at default settings

ChemBioEng Rev

doi: 10.3389/fimmu.2021.701163 77 RecalcatiSLocatiMMariniASantambrogioPZaninottoFDe PizzolMet al

Single-domain antibodies Also known as nanobodies, are antibodies derived from camelids that consist of only a variable heavy domain and as a result have a relatively low molecular weight (~15 kDa), hence the name nanobody