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and Frey, H.F., BMC Neuroscience , 2008, no

administration, heroin peaks very rapidly in the brain (T max = 1.52 min in the striatal extracellular fluid), where is then metabolized by esterases (t 1/2 = 12 min) [20, 31], and becomes undetectable within 1030 min (Fig

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However, caution must be exercised in the use of fluoride to treat OP, as excessive fluorine intake can lead to decreased bone strength and toughness, increased insulin resistance, elevated inflammatory factor levels, and disturbances of lipid metabolism, all of which can lead to adverse events (de Cssia Alves Nunes et al., 2016
