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These findings suggested that busulfan can significantly induce ROS creation and reduce antioxidants, leading to oxidative stress and lipid peroxidation in testicular tissue, which, in turn, can result in germ cell death, spermatogenesis impairment, and infertility (49)

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Such alterations in the shape and structure of the sperm are further exacerbated by ROS damage to the mitochondria, crucial for sperm function and energy production [37]

doi: 10.1007/BF01250574

In contrast, Moscat and Diaz-Meco have shown that p62 activates Raptor of mTORC1 leading to the inhibition of autophagy [280]