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The clinical and cellular phenotypes of the patient recapitulated the neurological and hematological defects previously described in Ireb2 / mice [162, 163], where the lack of IRP2 results in progressive neurodegeneration

As discussed previously, monomeric hIAPP binds to specific receptors in the membranes of cells to regulate glucose homeostasis and gastric emptying ( hIAPP has several positively charged residues on its N-terminal side, which are involved in the interaction of hIAPP with negatively charged lipids ( Cu 2+ binds to amylin, promoting the formation of toxic oligomers

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doi: 10.1016/j.cub.2006.01.065 14 CenikESFukunagaRLuGDutcherRWangYTanaka HallTMet al

Hepatocytes can incorporate SeMet in place of methionine in some proteins such as albumin, whereas the remaining SeMet is converted to Sec in the liver and other tissues via the transsulfuration pathway