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abcam), which has been known to induce AD-like astrocyte reactivity in vitro [27] upregulated the expression of candidate enzymes Putrescine Acetyltransferase ( Sat1 ), SIRT2 ( Sirt2 ) and ALDH1A1 ( Aldh1a1 ) involved in the putrescine-to-GABA degradation pathway (Fig

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