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Glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide, achieve significant weight loss primarily through central appetite suppression [9, 10]

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In this Opinion, we have proposed timing as a new factor to consider in the clinic, for the diagnosis, prevention and treatment of T2D

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13,37 However, acquired nevi (banal or atypical) themselves have minimal malignant potential, with the lifetime risk of a particular nevus transforming into melanoma estimated to be about 1 in 10,000, 38 and most cutaneous melanomas arise de novo (not in association with a nevus)
