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This highlights the need for strategies to overcome the restrictive nature of the BBB and the lack of drug targeting specificity which hinder delivery of adequate drug concentrations in the affected brain regions

If it looks cloudy, has particles, or changes color, dispose of the vial safely and contact your pharmacy for a replacement

Chawla, A., Repa, J

Nonenzymatic production of endogenous aldehydes One source of endogenous aldehydes is that generated by the non-enzymatic oxidation of lipids and carbohydrates by the superoxide anion radical ( O 2 ) and other reactive oxygen species (ROS)

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doi: 10.3389/fimmu.2025.1684075 Received 12 August 2025 Revised 07 November 2025 Accepted 14 November 2025 Published 26 November 2025 Volume 16 - 2025 Edited by Alessio Torcinaro, National Research Council (CNR), Italy Reviewed by Giuliana Papoff, National Research Council (CNR), Italy Veronica De Paolis, University of Rome Tor Vergata, Italy Updates Copyright 2025 Qin, Liu, Huang and Zhang