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Description
The glutathione-epothilone complex has an elevated molecular flexibility, higher solubility via the stronger interactions with aqueous environments and biological targets, with moderate lipophilicity
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These metabolic features of NRF2 addiction status provide clues for novel therapeutic strategies to target NRF2-addicted cancer cells.
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Gilbert and Crigler-Najjar syndrome is associated with decreases in UGT1A1 activity
