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Prolonged administration of thioacetamide to rats caused damage to the liver and altered the content of nuclear erythroid factor 2 (Nrf2) that led to a decrease in antioxidant capacity of the liver

doi: 10.1186/ar3318 42 KyriakidisNCKapsogeorgouEKGourziVCKonstaODBaltatzisGETzioufasAG

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Generally no extra supplementation is required unless indicated by a veterinarian due to a deficiency or medical condition

Various studies targeting ER stress signaling pathways and components of the UPR have demonstrated that CHAC1 expression is upregulated downstream of the ATF4-dependent signaling pathway (Figure 4)

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