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Over the next decades, this has prompted several modifications to make ADT increasingly more complete and potent in inhibiting AR, which have been the subject of excellent reviews [4, 7, 8]

Li, C., Zong, L., Zhong, Y., Zhang, M
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

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In contrast, in HEK-293T cells exposed to the same conditions, HSPA5 mRNA levels did not increase, whereas XBP1s expression was elevated in an HSF1-dependent manner