lost 10 lbs first week of tirzepatide How much have you so far? : r/tirzepatidecompound Down 10lbs in one month

When sleepiness disrupts your daily life, it should be checked

Easily digestible foods may be better tolerated by some individuals experiencing nausea

Glucagon Receptor (GCGR) : This receptor is mostly found in the liver and kidneys

It works on three hormone receptors at once (GLP-1, GIP, and glucagon), which is why some people call it a triple agonist or Triple G. Its half-life sits around 6 days, so a single weekly shot is enough to keep blood levels steady

That is a meaningful difference, and it reflects the additive nausea pathways from three receptors versus two

The short answer: most people begin to feel appetite suppression from tirzepatide within 3 to 7 days, with stronger and more consistent hunger control developing over 2 to 4 weeks, especially as the dose is gradually increased